Basically, using cisplatin (CDDP)-induced rat renal fibrosis model, we have demonstrated further significance for EMT in renal fibrosis; in this animal model, possible participations of transforming growth factor-β1 (TGF-β1), platelet derived growth factor (PDGF)-BB, prostaglandins, osteopontin (OPN), neutrophil gelatinase-associated lipocalin (NGAL) and bone morphogenic protein-6 (BMP-6) are discussed. Here, SPP1 is linked to renal fibrosis.