To determine whether the reported Axin1 accumulation in HCMV is mediated by TNKS, the effect of HCMV infection on the expression of TNKS 1 and 2, Axin1 and β-catenin was measured in HFFs at 24, 48 and 72 hours post infection (hpi). The gene discussed is AXIN1; the disease is infection.