DEAD (Asp-Glu-Ala-Asp) box helicase5 (DDX5, also known as p68) is found to act as a component of the Mastermind-like1(Maml1) protein complex for transcriptional coactivation and is also a novel regulator of oncogenic Notch signaling in T-ALL leukemic cells [82]. This evidence concerns the gene DDX5 and acute lymphoblastic leukemia.