EGFR and cholangiocarcinoma: Interestingly, in the human intrahepatic CC RBE cell line, EGFR degradation was impaired, which was associated with hypo-phosphorylation of Tyr1045 and with enhanced recycling of EGFR to the cell membrane, indicating that upregulation of Tyr1045 phosphorylation might be a beneficial molecular alteration in EGFR-targeted therapy [234].