So far, it has not been possible to model EGFR-induced liver cancer in mice, as all the attempts to generate GEMMs that overexpress EGFR have been unsuccessful [24], whereas transgenic overexpression has been successful for the EGFR ligands EGF [145,146], TGF-α [147,148], AR [149], BTC [150], HB-EGF [151] and EPGN [152]. Here, EGFR is linked to liver cancer.