Also, as shown in Figure 1, treatment of Caco-2 cells with ALS significantly inhibited the phosphorylation of AURKA at Thr288 in a concentration-dependent manner, whereas there was no significant change in the expression level of AURKA when treated with ALS at 0.1, 1, and 5 μM for 48 h. This evidence concerns the gene AURKA and amyotrophic lateral sclerosis.