AKT1 and cancer: Since we have observed that 3-AWA regulated eIF4E through modulation of Ras-Mnk and PI3K-AKT-mTOR pathways, here, this dual modulation by 3-AWA exhibits an excellent advantage of preventing the increase in eIF4E phosphorylation during mTOR inhibition that might otherwise, counteract mTOR inhibitor’s growth inhibitory effect in cancer cells.