In model 1 (adjusted for smoking, hypertension, drinking, diabetes, HbA1c, TSH, ALT, AST, GGT and UA), the risks of hypercholesterolemia, hyper-LDL-emia and hypertriglyceridemia were significantly elevated in the BNP Q1 group, while the risks for hypertriglyceridemia was progressively reduced in BNP Q2 and Q3 group. This evidence concerns the gene NPPB and familial hypercholesterolemia.