Administration of either an interfering peptide that disrupts DISC1-DRD2 binding or the DRD2 antagonist haloperidol to L100P mice blocked the increase in DISC1-DRD2 complex formation and the decrease in phospho-inhibition of GSK3β, and successfully reversed their schizophrenia-related behavioral deficits28. This evidence concerns the gene GSK3B and schizophrenia.