In agreement with this, our results show that higher N-Myc levels sensitize neuroblastoma to actinomycin D. In a wild-type p53 genetic background, the stronger effect of actinomycin D in MYCN amplified context should result in the activation of RPL5/RPL11/5S rRNA-MDM2-p53 checkpoint. This evidence concerns the gene MDM2 and neuroblastoma.