Important, we show that higher N-Myc levels, an indicator of bad prognosis, sensitize neuroblastoma to actinomycin D. Our data highlights the therapeutic potential of actinomycin D and suggests that low doses of this drug could be used in combination with other agents to take advantage of its dependence on p53, but avoid its non-specific effects. The gene discussed is MYCN; the disease is neuroblastoma.