SCN3B and Brugada syndrome: However, IL-2 can increase the mRNA level of genes which encodes the subunit for sodium channels, especially SCN3B.SCN3B encodes the β3 subunit for sodium channels and in 2009, Dan Hu, et al. detected a missense mutation (L10P) in exon 1 of SCN3B and provided the mutation led to an 82.6 % decrease in peak sodium current density, accelerated inactivation, slowed reactivation, a −9.6 mV shift of half-inactivation voltage and clinical manifestation of a Brugada syndrome, which is a disorder characterized by malignant ventricular arrhythmia and sudden death [17].