Of the 10 genes with mutations causatively linked to NBIA, 5 showed reduced transcript levels in Hfe−/−× Tfr2mut brain relative to wild-type (Table 1: Pla2g6; fatty acid 2-hydroxylase (Fa2h); ceruloplasmin (Cp); chromosome 19 open reading frame 12 (C19orf12); ATPase type 13A2 (Atp13a2)). This evidence concerns the gene FA2H and neurodegeneration with brain iron accumulation.