HFE and hemochromatosis: A new genetic mutant mouse model with simultaneous disruption of the Hfe and the Tfr2 genes (Hfe−/− × Tfr2mut) on an AKR background shows signs of early liver damage in the form of fibrosis, equivalent to mild clinical hemochromatosis.15 Hemochromatosis in patients with dual mutations in these two genes is typically of earlier onset but otherwise often clinically indistinguishable from hemochromatosis caused by either mutation alone.16, 17, 18, 19