ERBB2 and gastric cancer: Another phase III clinical trial, TyTAN, determined that lapatinib combined with paclitaxel as a second-line regimen for advanced gastric cancer in patients who exhibited amplification of HER-2 (FISH-positive) did not significantly alter the median OS time (11 vs 8.9 months, respectively) or the mean PFS compared with paclitaxel alone (5.4 vs 4.4 months, respectively) [31].