In an attempt to gain mechanistic insight into the neuroprotective effects of curcumin, we investigated if curcumin attenuates polyQ-induced apoptotic cell death, which underlies the symptoms of many neurodegenerative diseases including HD, in transgenic Drosophila expressing expanded Httex1p Q93 protein fragment driven by the pan-neuronal elav-GAL4. This evidence concerns the gene LGALS4 and neurodegenerative disease.