Importantly, silencing of KLF2 significantly reduced cell growth of MM cell lines (Fig. 4b and Supplementary Fig. 4a), inhibited DNA synthesis (Supplementary Fig. 4b) as well as triggered apoptosis, evidenced by caspase-8, -7 and PARP cleavage (Fig. 4c). This evidence concerns the gene KLF2 and Miyoshi myopathy.