Although KDM3A is a demethylase specific to H3K9me1 and me2 (ref. 7), the global H3K9me2 level was not significantly increased in MM cells transduced with KDM3A-specific shRNAs, similar to short interfering RNA-mediated KDM3A knockdown in HeLa cells32 (Fig. 2a). This evidence concerns the gene MBD2 and Miyoshi myopathy.