Importantly, silencing of KLF2 significantly reduced cell growth of MM cell lines (Fig. 4b and Supplementary Fig. 4a), inhibited DNA synthesis (Supplementary Fig. 4b) as well as triggered apoptosis, evidenced by caspase-8, -7 and PARP cleavage (Fig. 4c). This evidence concerns the gene CASP8 and Miyoshi myopathy.