To determine whether NAFLD-induced inflammation (which initially starts in the liver) induces CNS inflammation in mice fed with HFD that may account for the accelerated plaque burden in APP-Tg mice (Fig. 1), we performed cytokine gene expression analysis on the brains of WT and APP-Tg mice fed with either HFD or SD. This evidence concerns the gene APP and metabolic dysfunction-associated steatotic liver disease.