SMAD3 and head and neck squamous cell carcinoma: MiR-193b over-expression was also detected in head and neck squamous cell carcinoma [46], where neurofibromin1 (NF1) was described as a target, and in glioma [47], where this miR acted as an oncomiR by targeting Smad3, one of the major TGF-β signaling transducers.