Among them, miR-122, miR-21, miR-155, miR-23a, miR-143, whose target genes have been characterized in both NAFLD (i.e. PPARα, PTEN C/EBPβ, ORP8, G6PC) and HCC (i.e. CCNG1, IGF-1R, ADAM17, PTEN, SOCS1, C/EBPβ, FNDC3B) [14]. This evidence concerns the gene PTEN and hepatocellular carcinoma.