SIRT7 and cancer: MiR-125a-5p was described over-expressed in thyroid carcinomas [88] and hypo-expressed in human HCC [89], where it was shown to target the 3′UTR of SIRT7, a member of the Sirtuin family, whose activity in cancer, ER and genomic stress response, hepatosteatosis has already been investigated and is still controversial [90].