For example, the top-hit gene LUZP131 and the third-hit UBQLN432, albeit having no reported link with depression, have been demonstrated to be predominantly expressed in the brain, and the second-hit UGCG has been shown to be required in the maintenance of healthy intracellular interactions for nervous system stability and function33 (Supplementary Table S5). Here, UGCG is linked to depressive symptom measurement.