IFNG and infection: We found that Dectin-2 knock out (KO) mice were more susceptible to this infection than wild type (WT) mice, and our results suggest that Dectin-2-dependent IL-12 production may contribute to IFN-γ synthesis and subsequent production of serotype-specific anti-capsular polysaccharide IgG after S. pneumoniae infection, which may promote opsonization of this bacterium for engulfment.