To clarify the role of Dectin-2 in the host response to S. pneumoniae infection, we compared the production of proinflammatory cytokines and chemokines, such as IL-1β, TNF-α, IL-6, IFN-γ, IL-17A, and MIP-2, in BALF between WT and Dectin-2KO mice 12 h after infection. This evidence concerns the gene TNF and infection.