SHH and neoplasm: Statistically significant shorter OS was observed for patients with Shh overexpression in age by univariate and multivariate analysis (HR-2.12; p = 0.021, tumor stage (HR- 1.43; 0.002); tumor grade (HR: 1.45; p = 0.002); and receptor status (HR: 1.31; p = 0.004) [Table 5].