Expression of HIF1, CXCR4, SDF1, and VEGF have each been reported to have clinical implications in several malignancies, including primary CRC.16 Furthermore, multiple studies have shown the relevance of angiogenesis, measured by the formation of microvessels (i.e., microvessel density [MVD]) in CRC.17 Therefore, we hypothesized that these molecules may serve as prognostic markers in this population of metastasized CRC patients. The gene discussed is HIF1A; the disease is colorectal carcinoma.