Expression of HIF1, CXCR4, SDF1, and VEGF have each been reported to have clinical implications in several malignancies, including primary CRC.16 Furthermore, multiple studies have shown the relevance of angiogenesis, measured by the formation of microvessels (i.e., microvessel density [MVD]) in CRC.17 Therefore, we hypothesized that these molecules may serve as prognostic markers in this population of metastasized CRC patients. Here, CXCL12 is linked to colorectal carcinoma.