These interesting and ground-breaking developments could signal a new era in which the expression of certain molecules, e.g., VEGF, could aid not only in the treatment of our patients, but also in giving the treating CRS and HIPEC surgeon the much needed edge in the operating room by better visualization of even the smallest of tumor deposits.54–56 Despite limitations of our study such as a limited sample size, we believe the results shown are an important step toward furthering our knowledge of the molecular landscape of PM of CRC. This evidence concerns the gene VEGFA and colorectal carcinoma.