Oncogenic STAT3Sα-C rescued the toxicity of two independent STAT3 shRNAs in two ABC DLBCL cell lines HBL1 and OCI-Ly10, as evidenced by over 80% shRNA-expressing cells remaining in culture after 12 days of shRNA induction (Figure 3c), and thus was considered as a positive control with which to measure rescue by splice variants lacking the oncogenic mutation according to the formula: (% variant−% EV)/(% STAT3Sα-C−% EV). Here, STAT3 is linked to diffuse large B-cell lymphoma.