In this study, we used a knockdown/re-expression strategy to dissect the role of the STAT3 variants in the survival of STAT3-dependent ABC DLBCL cells; that is, whether expression of the individual STAT3 variants or different combinations rescues cell death caused by STAT3 shRNAs that target 3′UTR of endogenous STAT3. Here, STAT3 is linked to aneurysmal bone cyst.