Furthermore, we demonstrated that unhealthy mitochondria dramatically accumulate in normal intestinal epithelial cells and tumor cells in Mieap-deficient ApcMin/+ mice, leading to increased oxidative stresses in these Mieap-deficient cells.12 Consistent with previous observation,21 our data suggest that accumulation of unhealthy mitochondria and increased ROS generation by such unhealthy mitochondria may accelerate intestinal tumor initiation and progression in vivo. Here, SPATA18 is linked to intestinal neoplasm.