SPATA18 and colorectal cancer: Interestingly, p53 mutation was found in 9 of the 17 patients without Mieap/BNIP3 promoter methylation (52%) but only 4 of the 22 patients with Mieap/BNIP3 promoter methylation (18%), suggesting that p53 is likely inactivated in colorectal cancers having normal Mieap and BNIP3 statues (Table 1).