In fact, in this study, we showed that two colorectal cancer cell lines, HCT116 [p53 wt, Mieap-methyl (+), BNIP3-methyl (−)] and Lovo [p53 wt, Mieap-methyl (−), BNIP3-methyl (+)], failed to induce MALM in response to hypoxic stress. Here, SPATA18 is linked to colorectal cancer.