Hypertension is associated with loss-of-function mutations in genes that regulate normal renal salt reabsorption in the TALH and DCT including the Na-K-2Cl co-transporter gene; the inward rectifier K+ channel gene ROMK; and the Na-Cl co-transporter gene SLC12A3 [50–52]. The gene discussed is KCNJ1; the disease is hypertensive disorder.