Patients with anti-IFN-γ AAbs have been reported to be susceptible to various types of intracellular infections, for example, disseminated non-tuberculous mycobacterial infection, disseminated penicilliosis marneffei, non-typhoidal Salmonella bacteremia, cytococcosis, histoplasmosis, and disseminated herpes zoster, with a relative high mortality rate [1–4, 11, 21]. Here, IFNG is linked to histoplasmosis.