KRAS and cancer: The following mutations, which have been reported in many different cancer types, appeared more than once in multiple tumors: KRAS (G12C) x2; KRAS (G12D) x4; KRAS (G12V) x3; TP53 (R273C) x2; and BRAF (V600E) x3, resulting in a total of 57 unique MMs (S3 Table).