SLC9A3 and Crohn disease: was increased in stools of colitis-prone NHE3-/- mice [55], but was decreased in colitis-prone IL22-/- mice [42], and was decreased in biopsies from inflamed ileum of pediatric patients with Crohn’s Disease (CD) and ulcerative colitis (UC) [56] (two main forms of IBD), and was increased during remission in ileal biopsies from IBD patients, along with increased abundance of Prevotella and Bacteroides [57].