PGLYRP1 and colitis: Thus, in contrast to the similar effect on the sensitivity to colitis, each Pglyrp has a unique role in the development of other inflammatory diseases, which is consistent with Pglyrps not compensating for each other in mice deficient in a single Pglyrp. It is not known whether the above-mentioned changed sensitivities to non-intestinal inflammatory diseases are also based on the changes in microflora.