The interaction of Brd4 with viral transcription or replication factors such as LANA from KSHV, Tax from HTLV1, large T antigen from MCPyV, EBNA1 and EBNA2 from EBV and E2 from PVs seems to be another conserved feature among tumor viruses and was shown to be responsible for viral promoter regulation as well as viral replication [64–67]. This evidence concerns the gene CNTN2 and neoplasm.