The circulating neutrophils could act as a surrogate for the number of tumor-associated neutrophils (TANs), which act as adhesive adapters between circulating tumor cells and the metastatic target [18] and which play an important role in tumor angiogenesis and growth by secreting VEGF and matrix metalloproteinase 9 [19, 20]. The gene discussed is MMP9; the disease is neoplasm.