TNF and cancer: This process was known to be initiated with various chemokines that tumor cells secrete and promoted by pro-inflammatory cells, which infiltrate into the tumor microenvironment and make it favorable for cancer progression by the secretion of inflammatory mediators, such as interleukins, tumor necrosis factor-α (TNF-α) and vascular endothelial growth factor (VEGF) [4, 16, 17].