TGFB1 and fibrosis: However, when control diet intervention was introduced only at the stage of the appearance of fibrosis, i.e., after HFC diet feeding for 8 weeks, the intervention could neither completely reset serum ALT and hepatic TC levels and fibrosis nor the elevated expression of many inflammatory- and fibrosis-related genes such as TNF-α, IL-6, TGF-β1, PDGFβR, Col1α1, MMP-2, and TIMP-1.