Previous studies on LRRK2 PD form using Dm mutants (dLRRK2) did not clarify the role of LRRK2 in Drosophila, both in mutants gain-of-function for the kinase domain[15][34]and loss-of-function (LRRKex1 mutant) [35–37]. The gene discussed is LRRK2; the disease is Parkinson disease.