LRRK2 and Parkinson disease: The aim of this paper was twofold: on one hand to confirm the validity of the LRRKex1mutant [35][37], from now on named LRRK2 WD40 loss-of-function (LRRK2WD40), as animal model of parkinsonism in Dm; on the other hand, to investigate the antiparkinsonian potential of the standardized methanolic extract of Wse roots on this mutant, as compared to Dm wild type (WT, Canton-S).