Similarly, as shown in Fig 2B, the circulating levels of VEGF-A (GM of 7.72 ng/ml in cavitary vs. 2.81 ng/ml in non-cavitary disease), VEGF-C (GM of 1.38 ng/ml in cavitary vs. 0.66 ng/ml in non-cavitary disease) and VEGF-R2 (GM of 7.72 ng/ml in cavitary vs. 2.26 ng/ml in non-cavitary disease) were significantly higher in PTB individuals with cavitary disease compared to those without cavitary disease. The gene discussed is VEGFA; the disease is glycogen storage disease VI.