First, consistent with the ambient postprandial hyperinsulinemia present in MetS mice 1 h after oil gavage, the intestines of these mice, as compared with controls, had much higher levels of phosphorylated AKT (Fig 6B), higher mRNA content of the insulin receptor (IR) and insulin receptor substrate 1 (IRS1) (Fig 6C). This evidence concerns the gene IRS1 and metabolic syndrome.