CRY2 and type 2 diabetes mellitus: More importantly however, we describe herein a novel aspect of the four genetic CRY2 variants that may explain their lack of association with type-2 diabetes: the fasting glucose-raising alleles were, concomitantly, associated with ~ 30% reduced liver fat content in vivo, and liver fat is a well-recognized risk factor for insulin resistance and type-2 diabetes [36,37].