Further, a non-randomized, phase II study of abemaciclib in patients with brain metastases secondary to HR-positive breast cancer is also recruiting (NCT02308020), and a neoadjuvant study of abemaciclib in postmenopausal women with HR-positive, HER2-negative breast cancer is also planned (NCT02441946). Here, ERBB2 is linked to breast carcinoma.