We observed that cell proliferation was significantly inhibited in the NCI-H1975 and PC-9 lung adenocarcinoma cell lines by not only siROR1 treatment but also the knockdown of either cavin-1 or CAV1 (Supplementary Fig. 9a), suggesting that the scaffold function of ROR1 for caveolae formation may be crucially involved in ROR1-mediated TTF-1/NKX2-1 lineage-survival signalling. This evidence concerns the gene TTF1 and lung adenocarcinoma.