The biomarker signature with the highest potential to discriminate between culture-confirmed TB cases and TST-negative household siblings (identified by Lasso regression, AUC 96.2%, Fig. 3B, Table 2), provided further confirmation for the discriminatory role for CCR7, CD14, FCGR1A, MMP9, SEC14L1, TGFBR2 and TIMP2, all identified both by single biomarker analyses and global tests. This evidence concerns the gene TGFBR2 and tuberculosis.