TIMP2 and tuberculosis: The biomarker signature with the highest potential to discriminate between culture-confirmed TB cases and TST-negative household siblings (identified by Lasso regression, AUC 96.2%, Fig. 3B, Table 2), provided further confirmation for the discriminatory role for CCR7, CD14, FCGR1A, MMP9, SEC14L1, TGFBR2 and TIMP2, all identified both by single biomarker analyses and global tests.