CYP2E1 and metastatic neoplasm: Based on the cumulative ranks, the top 5 genes identified were CPT1C, CAV1, CD36, MLXIPL, and CYP2E1. The fatty acid uptake genes CAV1 and CD36, as well as the carbohydrate response element binding protein encoding MLXIPL, also exhibited significant accumulation of copy number gain in the pan-cancer metastatic tumors (Fig. 3A).