Finally, in HGSOC from the TCGA cohort, although miR-200c/141 expression levels were globally high, the methylation status of the PTPN6 promoter was significantly negatively correlated with the miR-200c/141 expression levels (Supplementary Fig. 7c), highlighting the relevance of our findings not only in cultured cell lines but also in human cancers. Here, PTPN6 is linked to cancer.