The TN clusters (TN and TN+Her2) include proliferative proteins (MCM3 and 5), translation related proteins (RCL1, MRPS27, EIF2S2 and EEF1G) and metabolic enzymes (glutaminase and hexokinase 2), which reflect the higher dependence on glutamine and glucose of TN versus the other tumours. This evidence concerns the gene HK2 and neoplasm.