With over 60% of CdLS cases associated with NIPBL mutations, the etiology of CdLS can likely be at least partially elucidated by studying the loss of function of NIPBL. To investigate the potential functions of NIPBL, we first analyzed the publicly available data of ChIP followed by massive parallel deep sequencing (ChIP-seq) of NIPBL in human LCLs (Sequence Read Archive [SRA]: ERR139553). This evidence concerns the gene NIPBL and Cornelia de Lange syndrome.