TP53 and neoplasm: Lastly, in line with our CDM and xenograft data (Figures 2 and 3), OD-GLCM analysis of mutant metastatic lines also revealed a reduction in contrast and a more uniform, malleable organization of E-cadherin-GFP distribution compared with primary tumor cells isolated from Pdx1-Cre; KrasG12D; p53−/−; E-cadherin-GFP mice (Figures S6J and S6K), suggesting that E-cadherin destabilization is maintained in mutant p53 metastatic cells derived from the E-cadherin-GFP mouse.