CDH1 and cancer: Using this approach, we demonstrated that locally invading cells had a significantly lower immobile fraction of E-cadherin-GFP compared with non-invading cells, illustrating that, in cancer cells that retain E-cadherin expression, mobilization rather than loss of E-cadherin can play a role in reducing cell-cell adhesions, leading to more malleable, motile, and invasive tumor behavior (Friedl et al., 2012, Lamouille et al., 2014, Shamir et al., 2014).