TP53 and familial pancreatic carcinoma: The resulting invasive mutant p53−/− R175H and non-invasive p53−/− vector cells expressing E-cadherin-GFP (Figure 2A; Movie S3) serve as a fluorescent model system to gauge the initial spatiotemporal regulation of E-cadherin in pancreatic cancer (Morton et al., 2010b, Muller et al., 2013, Tan et al., 2014) without affecting fundamental processes such as cell proliferation or invasive capacity (Figures S1C and S1D).