Recently we demonstrated that Src kinase, which is known to induce the disruption of E-cadherin-based cell-cell junctions either directly (Avizienyte et al., 2002, Calautti et al., 1998, Frame et al., 2002) or indirectly via the stroma (Yang et al., 2010), plays a prominent role in invasive pancreatic cancer (Morton et al., 2010a). The gene discussed is CDH1; the disease is familial pancreatic carcinoma.