Our assessment of the E-cadherin-GFP mouse, in the context of the comprehensively characterized KrasG12D/+; Trp53R172H/+; Pdx1-Cre (KPC) mouse model of pancreatic cancer, suggests that we gauged expression levels well, providing enough fluorescence for detection of pre- and post-photobleaching events without affecting primary tumor growth and metastasis. This evidence concerns the gene CDH1 and familial pancreatic carcinoma.