MLC1 and acute myeloid leukemia: In acute myeloid leukemia (AML), ROCK1 depletion by genetic knockout or ROCK inhibition with H-1152, Y27632, or fasudil reduced the survival of malignant cells bearing oncogenic form of KIT, FLT3, and BCR-ABL through suppressing MLC phosphorylation (Mali et al. 2011).