RHO and hepatocellular carcinoma: In hepatocellular carcinoma, the loss of the antagonist RhoE leads to increased ROCK activity (Ma et al. 2013); in invasive lobular carcinoma, p120-cadherin inhibits the antagonist myosin phosphatase Rho-interacting protein leading to increased Rho/ROCK activity (Schackmann et al. 2011); in pancreatic and liver cancer metastasis, the overexpression of tropomyosin-related kinase B leads to binding and sequestering Rho GDP dissociation inhibitor, subsequently activating Rho and its downstream pathways (Li et al. 2009).