ROCK1 and cancer: Decreased expression of the miRNAs in cancer tissues leads to increased ROCK expression/activity and increased migration, invasion, or proliferation, which can be rescued by either overexpression of the miRNAs or inhibition of ROCK1 by either a ROCK inhibitor (Y27632) or ROCK1 siRNA molecules (An et al. 2013; Hu et al. 2014; Li et al. 2013b, 2014a; Ueno et al. 2011; Zheng et al. 2011; Zhou et al. 2013).