ROCK1 and cancer: Recently developed ROCK1 and ROCK2 isoform-specific genetically modified mouse models have offered a unique opportunity to analyze in vivo physiological and pathological functions of ROCK1 and ROCK2 (Lee et al. 2014b; Rikitake et al. 2005; Shi et al. 2011; Shimizu et al. 2005, 2013; Soliman et al. 2015; Thumkeo et al. 2003; Zhang et al. 2006), including cancer development and progression (Mali et al. 2011; Samuel et al. 2011).