ROCK1 was found to be a target of miR-145 (Wan et al. 2014) and miR-124 (An et al. 2013) in glioma, miR-145 (Li et al. 2014a) and miR-340 (Cai et al. 2014; Zhou et al. 2013) in osteosarcoma, miR-148a (Zheng et al. 2011), miR-135a (Shin et al. 2014) and miR-124 (Hu et al. 2014) in gastric cancer, miR-186 (Cui et al. 2014) and miR-148a (Li et al. 2013b) in non-small cell lung cancer cells, miR146a (Lin et al. 2008) and miR-135a (Kroiss et al. 2015) in prostate cancer, miR-584 (Ueno et al. 2011) in renal cancer, and miR-1280 (Majid et al. 2012) in bladder cancer. Here, ROCK1 is linked to central nervous system cancer.