At centrosomes, morgana/chp-1 directly binds ROCK2 and prevents ROCK2 activation by nucleophosmin; the down-regulation of morgana in mice or in patients with atypical chronic myeloid leukemia leads to increased ROCK2 kinase activity, which results in centrosome amplification and cytogenetic abnormalities (Di Savino et al. 2015; Ferretti et al. 2010). The gene discussed is CHORDC1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.