ROCK2 and neoplasm: In tumor cells, ROCK1 and ROCK2 have recently been reported to have functional differences in regulating adhesion, migration, proliferation, and gene expression, but the underlying mechanisms are not fully understood (Inaba et al. 2010; Mertsch and Thanos 2014; Montalvo et al. 2013; Rochelle et al. 2013; Vega et al. 2011; Vigil et al. 2012; Wang et al. 2014).