We also noted that by day 40 there were fewer additional tumours in both the MMTV-NIC PTEN+/+ and MMTV-NIC PTEN+/− animals treated with AZD8931, and although this did not reach statistical significance the reduction in tumour burden was greater in the MMTV-NIC PTEN+/+ mice, consistent with the increased sensitivity of the MMTV-NIC PTEN+/+ tumours to AZD8931 (median values for tumours per mouse: MMTV-NIC PTEN+/+, vehicle=5; MMTV-NIC PTEN+/+, AZD8931=1; MMTV-NIC PTEN+/−, vehicle=6; MMTV-NIC PTEN+/−, AZD8931=3; P=0.1025, Kruskal–Wallis). The gene discussed is PTEN; the disease is neoplasm.