Third, we lacked cardiac biopsy evidence in subjects with -/- of c.-100~-110 to show the actual changes in δ-SG gene transcription and in the DCM patients with the co-occurred -/- of c.-100~-110 and 848A/G to further show the mildly decreased plasma membrane localization of δ-SG-Q283R. The gene discussed is DSG1; the disease is familial dilated cardiomyopathy.