MDM2 and follicular lymphoma: The downregulation of Mdm2 by MI-219 appears to be associated with p53-dependent apoptosis in follicular lymphoma.48 Lozano's group demonstrated that p53 restoration in Mdm2-overexpressing tumors inhibits proliferation but does not induce apoptosis,49 suggesting that high levels of Mdm2 has anti-death activity.