To test the potential value of targeting the mechanism involving Bcl-2 interaction with IP3Rs in SCLC, we employed BIRD-2, a decoy peptide previously developed in our laboratory and found to induce Ca2+-mediated apoptosis in Bcl-2-positive lymphoid malignancies.29, 31, 32 We report here for the first time that BIRD-2 has single agent activity in SCLC, selectively inducing apoptosis in 13 of the 15 SCLC lines but not in NSCLC cells or normal lung epithelial cells. The gene discussed is BCL2; the disease is small cell lung carcinoma.