BCL2 and non-small cell lung carcinoma: To test the potential value of targeting the mechanism involving Bcl-2 interaction with IP3Rs in SCLC, we employed BIRD-2, a decoy peptide previously developed in our laboratory and found to induce Ca2+-mediated apoptosis in Bcl-2-positive lymphoid malignancies.29, 31, 32 We report here for the first time that BIRD-2 has single agent activity in SCLC, selectively inducing apoptosis in 13 of the 15 SCLC lines but not in NSCLC cells or normal lung epithelial cells.