APOE and Alzheimer disease: To determine the specific brain regions in which ApoE changes were observed in treated 3xTg-AD mice, we analyzed its expression in the CA1, CA3, and DG regions of the hippocampus, in the neocortex (retrosplenial agranular and granular cortex (RSA/RSG Cortex) and entorhinal cortex by confocal microscopy and WB.