In the hippocampus, ABCA1 expression increased 3-fold in treated WT compared with untreated WT (n = 5 treated and untreated, p<0.05); there was a 3-fold increase in ABCA1 in treated 3xTg-AD compared with untreated WT and untreated 3xTg-AD animals (n = 5 per group, p<0.01) (Fig 4B). This evidence concerns the gene ABCA1 and Alzheimer disease.