In cerebral cortex, ABCA1 expression increased 6-fold in treated WT compared with untreated WT (n = 5 per group, p<0.001); there was a 3-fold increase in ABCA1 expression in treated 3xTg-AD compared with untreated WT and untreated 3xTg-AD animals (n = 5 per group, p<0.05) (Fig 4B). Here, ABCA1 is linked to Alzheimer disease.