SREBF1 and digestive system neoplasm: Hongwei et al. noted that cigarette smoking inactivates 5’- adenosine monophosphate-activated protein kinase (AMPK) by dephosphorylation and promoted triglyceride accumulation in hepatocytes via activation of sterol regulatory element binding protein-1 (SREBP-1), inducing fatty liver in mice fed a high fat diet [19].