Another recent study (19) utilized several oligomer-directed quantitative assays, including a high specificity binding assay based on the affinity of certain AβO for the cellular form of the prion protein (PrPC) (PrP-ELISA or PLISA) (20), to assay AβO across brain tissue from multiple AD mouse models and human brain samples. The gene discussed is ABO; the disease is Alzheimer disease.