Aβ oligomers (AβO) appear to be the most neurotoxic species, triggering various processes that underlie AD, including synaptic dysfunction, impairment of long-term potentiation (LTP), Ca2+ dysregulation, mitochondrial dysfunction, endoplasmic reticulum stress, and the activation of pro-apoptotic pathways leading to cell death (4, 5). Here, ABO is linked to Alzheimer disease.