For patients with metastatic disease, the subHR for SOC + Doc was 0·80 (95% CI 0·65–0·99; p=0·033), for SOC + ZA was 0·92 (0·75–1·12), and for SOC + ZA + Doc was 0·78 (0·64–0·96); for patients with non-metastatic disease, the subHR for SOC + Doc was 0·82 (95% CI 0·48–1·40; p=0·475), for SOC + ZA was 1·08 (0·66–1·76), and for SOC + ZA + Doc was 0·81 (CI 0·46–1·43). This evidence concerns the gene UBXN11 and metastatic neoplasm.